Assessment of Homocysteine Level in Plasma of Iraqi Women with Polycystic Ovary Syndrome and Insulin Resistance

Polycystic ovary syndrome (PCOS) is a common endocrine disorder which affects women at reproductive age. This study was aimed to detect homocysteine level in women with polycystic ovary syndrome. The present study was carried out for (51) PCOS women and (10) healthy women as controls at High Institute for Infertility Diagnosis and Assisted Reproductive Technologies/AL-Nahrain University, from February to August, 2014. Homocysteine test and OGTT were performed for all women. Age and BMI were recorded for all subjects and duration of infertility recorded for infertile PCOS women. Significant increment (P<0.05) in homocysteine level was observed in obese PCOS group with duration of infertility >9 years, but the differences in homocysteine was not significant (P>0.05) between PCOS women and controls, and among PCOS subgroups. Significant increment (P<0.05) in OGTT was recorded in obese patients when compared with controls. The present study concluded that homocysteine elevation in PCOS women related to obesity and insulin resistance. Also, it has a relation with duration of infertility.